In " Peter's Two Dads", Francis attends Meg's 17th birthday party, and is crushed by a drunk Peter while attempting a unicycle trick to entertain the party guests as "Pee-Pants the Inebriated Hobo Clown." The injuries prove fatal, and as Francis is dying in the hospital, his last words to Peter before his death are, "Peter… you're a fat, stinking drunk." An obsessively devout Roman Catholic, he hates Lois because she is not a Catholic, and often calls her a " Protestant whore", disapproves of his son's family's lifestyle, and frequently attempts to force his religious views on them.
He was once married to Peter's biological mother Thelma Griffin.